Product Identification

Product Name

2-Hydroxy-4-amino-5-fluoropyrimidine

Synonyms

4-Amino-5-fluoro-2(1H)-pyrimidinone
4-Amino-5-fluoro-3H-pyrimidin-2-one
Alcobon
Ancobon
Ancotil
Flucytosine

CAS

2022-85-7

Formula

C4H4FN3O

Molecular Weight

129.09

EINECS

217-968-7

RTECS

HA6040000

RTECS Class

Drug; Mutagen; Human Data

Merck

13,4151

Beilstein/Gmelin

127285

Beilstein Reference

4-25-00-03688

Physical and Chemical Properties

Solubility in water

15 g/L

Melting Point

165

Boiling Point

298

pKa/pKb

3.26(at 25℃) (pKa)

Partition Coefficient

-1.07

Usage

Medication.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Store protected from light.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

No hazard expected in normal industrial use.

EC Risk Phrase

R 40

EC Safety Phrase

S 22 36/37

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron.

Respirators

A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.

Exposure Effects

Prolonged or repeated exposure may cause adverse reproductive effects.

Fire Fighting Measures

Flash Point

296

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride.