Product Identification

Product Name

Chlorothiazide

Synonyms

6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Alurene
Chlorosal
Chlorothiazid
Chlorthiazide
Chlortiazid

CAS

58-94-6

Formula

C7H6ClN3O4S2

Molecular Weight

295.73

EINECS

200-404-9

RTECS

DK9450000

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,2221

Beilstein/Gmelin

34611

Beilstein Reference

4-27-00-08036

Physical and Chemical Properties

Appearance

Crystals; white powder.

Melting Point

358.5

Boiling Point

410

pKa/pKb

6.85 (pKa)

Partition Coefficient

-.24

Usage

Diuretic sodium salt.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.

Fire Fighting Measures

Fire Fighting

Fires involving this material can be controlled with a carbon dioxide, dry chemical or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

No data.