Product Identification

Product Name

(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride

Synonyms

Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, hydrochloride, (aR)-
Isophrin hydrochloride
l-m-Hydroxy-a-[(methylamino)methyl]benzyl alcohol hydrochloride
meta-Synephrine hydrochloride
neo-Synephrine hydrochloride
R-(-)-m-Synephrine hydrochloride

CAS

61-76-7

Formula

C9H14ClNO2

Molecular Weight

203.67

EINECS

200-517-3

RTECS

DO7525000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7440

Beilstein/Gmelin

4158948

Beilstein Reference

3-13-00-02236

Physical and Chemical Properties

Appearance

Odorless white microcrystalline powder. Bitter taste.

Melting Point

138 - 141

pKa/pKb

pK1 8.77; pK2 9.84(at 25℃) (pKa)

Usage

Adrenergic drug.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 22 36/37/38

EC Safety Phrase

S 26 36/37/39

UN (DOT)

1760

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents, acids, acid chlorides, acid anhydrides.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1760

Hazard Class

8

Packing Group

I; II; III