Product Identification

Product Name

Heparin

Synonyms

6-[5-Acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid
alpha-Heparin
Depo heparin
HED heparin
Heparinate
Heparinic acid

CAS

9005-49-6

Formula

C26H42N2O37S5

Molecular Weight

1134.93

EINECS

232-681-7

RTECS

MI0700000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Natural Product

Beilstein/Gmelin

NA

Physical and Chemical Properties

Appearance

White or pale-colored amorphous powder. Nearly odorless.

Solubility in water

soluble

Usage

Anticlotting agent.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Orally ingested heparin is not absorbed from the gastrointestinal tract and will not result in toxicity. Refer to the parenteral exposure section for treatment recommendations following toxic parenteral exposures.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Hemothorax may occur. Pulmonary edema and/or embolism have been reported.

Skin

Hematoma and ecchymoses have been frequently noted especially with intramuscular injections. Skin necrosis is common with subcutaneous heparin injections; dermatitis, eczema, and generalized urticaria have been reported.

Ingestion

Hemothorax may occur. Pulmonary edema and/or embolism have been reported.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

hallucinations and distorted perceptions may occur. Intracerebral hemorrhage has been reported. Compressive neuropathy may occur. Reports of increased rates of abnormal pregnancies and fetal outcomes can be due to maternal co-morbidities. <br>Heparin is classified as Pregnancy Category C.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

Hygroscopic; ampuled solution may be stored @ room temperature for at least 12 mo sodium salt.

Incompatibilities

Strong oxidizing agents.