Product Identification

Product Name

2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one

Synonyms

2-Amino-1,9-dihydro-9-((2-Hydroxyethoxy)methyl)-6H-purin-6-one
9-((2-Hydroxyethoxy)methyl)guanine
Aciclovir
Acycloguanosine
Vipral
Virorax

CAS

59277-89-3

Formula

C8H11N5O3

Molecular Weight

225.21

EINECS

261-685-1

RTECS

UP0791400

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,148

Beilstein/Gmelin

1219402

Beilstein Reference

5-26-18-00045

Physical and Chemical Properties

Appearance

Crystals from methanol.

Solubility in water

Very soluble

pKa/pKb

9.18 (pKa)

Partition Coefficient

-1.76

Heat Of Vaporization

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin

Rashes have been seen after therapeutic administration. Reactions at the injection site have also been seen.

Ingestion

Nausea and vomiting are common adverse effects of high-dose therapy with these agents.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

adverse effects include neurotoxicity which resembles an extension of viral infection into the central nervous system. Most commonly, mental status changes and involuntary movements occur. Neurologic toxicity is generally reversible. Seizures have been reported following overdose, but are rare. Lethargy, fatigue, irritability, depression, agitation, stupor and coma have been reported following intravenous acyclovir, particularly rapid infusions. Hallucinations may occur. Occasional myoclonus with muscle fasciculations, hyperactive tendon reflexes, and tremor have been noted with iv use. Headache is common with high doses of these agents.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.