Product Identification

Product Name

Valproic acid

Synonyms

2-Propylpentanoic acid
2-Propylvaleric acid
Di-n-propylacetic acid
Mylproin

CAS

99-66-1

Formula

C8H16O2

Molecular Weight

144.21

EINECS

202-777-3

RTECS

YV7875000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,10049

Beilstein/Gmelin

1750447

Beilstein Reference

3-02-00-00807

EC Class

harmful, irritant

Physical and Chemical Properties

Appearance

Clear colorless liquid.

Solubility in water

Soluble

Boiling Point

220

Vapor Pressure

0.044 (25 C)

Density

0.9215 g/cm3 (0 C)

pKa/pKb

4.82 (pKa)

Partition Coefficient

2.75

Heat Of Vaporization

50.3 kJ/mol

Usage

Medication.

Vapor Density

4.97

Refractive Index

1.4236 (20 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Do not breathe vapors.

Hazards Identification

Inhalation

Causes chemical burns to the respiratory tract. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Skin

May cause severe irritation and possible burns.

Eyes

Contact with eyes may cause severe irritation, and possible eye burns.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May be harmful if swallowed. May cause central nervous system depression. May cause stupor, drowsiness, unconsiousness, or coma (if ingested in large amounts). Causes changes in exocrine pancreas and sleep disturbances.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 22 34

EC Safety Phrase

S 26 36/37/39 45

UN (DOT)

3265

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause reproductive and fetal effects.

Fire Fighting Measures

Flash Point

111

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Water may be ineffective. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation.

Stability and Reactivity

Disposal Code

4

Incompatibilities

Oxidizing agents, reducing agents, bases.

Stability

Stable under normal temperatures and pressures.

Decomposition

Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3265

Hazard Class

8

Packing Group

I; II; III

HS Code

2915 90 80