Product Identification

Product Name

Tobramycin

Synonyms

(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
1-Epitobramycin
3'-Deoxykanamycin B
Deoxykanamycin B
Distobram
O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1[R]6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1[R]4)]-2-deoxy-D-streptamine

CAS

32986-56-4

Formula

C18H37N5O9

Molecular Weight

467.52

EINECS

251-322-5

RTECS

WK2100000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Natural Product

Merck

12,9628

Beilstein/Gmelin

1357507

Beilstein Reference

6-18

Physical and Chemical Properties

Appearance

white solid

Solubility in water

Very soluble

Melting Point

168 - 178

Vapor Pressure

9E-28 (25 C)

pKa/pKb

13.07 (pKa)

Heat Of Vaporization

128.7 kJ/mol

Usage

Irreversible inhibition of bacterial protein synthesis. Spectrum of activity: gram negative bacteria. Not effective against enterococci. .

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store at -20 C

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

Toxic if swallowed.

Hazards

Emits toxic fumes under fire conditions.

UN (DOT)

1544

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves.

Respirators

Government approved respirator.

Exposure Effects

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

Fire Fighting Measures

Flash Point

423

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Non-Combustible

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1544

Hazard Class

6.1

Packing Group

II