Product Identification

Product Name

Etretin

Synonyms

9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Neotigason
Soriatane

CAS

55079-83-9

Formula

C21H26O3

Molecular Weight

326.44

EINECS

259-474-4

RTECS

RA8460000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,114

Beilstein/Gmelin

2158933

Beilstein Reference

6-10

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

219 - 220

Boiling Point

521

Vapor Pressure

1E-11 (25 C)

pKa/pKb

4.79 (pKa)

Heat Of Vaporization

83.6 kJ/mol

Usage

Used to treat severe psoriasis. Only used when other treatments prove ineffective.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store at 2-8 C

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

Causes skin irritation. May be harmful if absorbed through the skin.

Eyes

Causes eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

61 36/38 50/53

EC Safety Phrase

53 37/39 45 60 61

UN (DOT)

3077

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Toxic. Dangerous for the environment. May cause harm to the unborn child. Irritating to eyes and skin. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Fire Fighting Measures

Flash Point

180

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

May burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3077

Hazard Class

9

Packing Group

III