Product Identification

Product Name

Calcium folinate

Synonyms

Calcium 5-formyltetrahydrofolate
Calcium leucovorin
Calcium L-folinate
Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl) amino)benzoyl)-, calcium salt (1:1), L-
Lederfoline

CAS

1492-18-8

Formula

C20H23CaN7O7

Molecular Weight

513.52

EINECS

216-082-8

RTECS

MA0600500

RTECS Class

Drug

Beilstein/Gmelin

5723924

Physical and Chemical Properties

Appearance

odorless white to yellow white solid

Melting Point

240-250

Heat Of Vaporization

Usage

An adjuvant used in cancer chemotherapy involving the drug methotrexate.

Vapor Density

20.8

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from light and air.

Handling

Wash hands before eating. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Keep container tightly closed. Store protected from light. Use and store under nitrogen. Store and handle protected from air. Wash clothing before reuse. Discard contaminated shoes.

Hazards Identification

Ingestion

May cause digestive tract disturbances. Expected to be a low ingestion hazard.

Inhalation

May cause respiratory tract irritation. In rare instances, exposure may cause sensitization, resulting in inflammation of the mucous membranes and in eczematous eruptions.

Skin

May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable at normal temperatures in tightly closed containers under an inert atmosphere.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.