Product Identification

Product Name

(+)-cis-3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)one monohydrochloride

Synonyms

1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4- methoxyphenyl)-, monohydrochloride, cis-(+)
Anginyl
Angizem
Britiazim
Bruzem
Calcicard

CAS

33286-22-5

Formula

C22H27ClN2O4S

Molecular Weight

450.98

EINECS

251-443-3

RTECS

DL0310000

RTECS Class

Drug; Reproductive Effector; Human Data

Beilstein/Gmelin

4228706

Physical and Chemical Properties

Appearance

odorless white powder

Melting Point

210 - 215

Usage

Calcium channel blocker.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract. Ingestion of 1 to 30 grams of soluble silver salts can cause argyria, which is characterized by permanent blue-gray pigmentation of the skin, mucous membranes, and eyes. Pigmentation is permanent.

Inhalation

May cause respiratory tract irritation. May be harmful if inhaled.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.