Product Identification

Product Name

2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

Synonyms

2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
3-Chloro-10-chlorperazine
Capazine
Chlormeprazine

CAS

58-38-8

Formula

C20H24ClN3S

Molecular Weight

373.95

EINECS

200-379-4

RTECS

SO2700000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,7942

Beilstein/Gmelin

48537

Beilstein Reference

4-27-00-01307

Physical and Chemical Properties

Appearance

Clear, pale yellow, viscous liquid.

Solubility in water

Insoluble.

Melting Point

220

Boiling Point

224 - 234 (0.5 torr)

Partition Coefficient

4.88

Usage

Antiemetic, antipsychotic. In the treatment of vertigo.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Protect from light. Keep in a tightly closed container in a cool, dry location.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose.

Skin

Itching, redness, swelling, irritation.

Eyes

Irritation.

Ingestion

Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Not required for the normal use of this material.

Exposure Effects

Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Use protective equipment. Absorb spill with inert material. Shove into a container for disposal.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

No data.