Product Identification

Product Name

6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide

Synonyms

2,3-Dihydro-3-hydroxy-2-Imino-6-(1-piperidinyl)-4-pyrimidinamine
2,4-Diamino-6-piperidinopyrimidine 3-oxide
6-Amino-1,2-dihydro-1-hydroxy-2-Imino-4-piperidinopyrimidine
Aalopexil
Alostil
U-10,858

CAS

38304-91-5

Formula

C9H15N5O

Molecular Weight

209.25

EINECS

253-874-2

RTECS

UV8200000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,6290

Beilstein/Gmelin

886240

Beilstein Reference

5-25-12-00317

Physical and Chemical Properties

Appearance

Crystals from methanol-acetonitrile. Odorless. Solutions are colorless to light yellow.

Melting Point

248

pKa/pKb

4.61 (pKa)

Usage

Medication.

First Aid Measures

Ingestion

Immediately seek medical assistance.

Inhalation

Remove from exposure. Seek medical assistance.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with copious amounts of water. Seek medical assistance.

Handling and Storage

Storage

Keep in a cool, dry location. Keep containers closed when not in use. Protect from light.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Pulmonary edema has been reported following buflomedil overdoses. Respiratory depression may occur with buflomedil intoxication.

Skin

May cause irritation, allergic contact dermatitis.

Eyes

Burns, irritation.

Ingestion

Nausea and vomiting are common following therapeutic administration of fenoldopam.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Headache, dizziness and sweating may occur with any of the vasodilators. Peripheral neuropathy has been reported following long term hydralazine therapy. Hyperglycemic, non-ketotic coma may occur with diazoxide. Seizures and coma may occur with buflomedil toxicity.

Fire Fighting Measures

Fire Fighting

Extinguish using water, carbon dixoide or dry chemical powder. Use a SCBA and full-body protective equipment.

Accidental Release Measures

Small spills/leaks

Absorb spilled solutions wiht papter towls or other appropriate media. For solid, sweep up. Transfer to suitable container for later disposal.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.