Product Identification

Product Name

4'-Hydroxy-3'-methoxyacetophenone

Synonyms

1-(4-Hydroxy-3-methoxyphenyl)ethanone
4-Acetyl-2-methoxyphenol
4-Acetylguaiacol
4'-Hydroxy-3'-methoxyacetophenone
Acetoguaiacone
Acetovanillone

CAS

498-02-2

Formula

C9H10O3

Molecular Weight

166.18

EINECS

207-854-5

RTECS

AM8800000

RTECS Class

Drug; Mutagen

Merck

13,746

Beilstein/Gmelin

637373

Beilstein Reference

4-08-00-01814

Physical and Chemical Properties

Appearance

Light yellow to yellow solid. Faint vanilla odor.

Solubility in water

Slightly soluble

Melting Point

115

Boiling Point

295

Vapor Pressure

0.0008 (25 C)

pKa/pKb

8.17 (pKa)

Partition Coefficient

1.38

Heat Of Vaporization

55.9 kJ/mol

Usage

A plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis.

First Aid Measures

Ingestion

Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep container closed when not in use.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

The toxicological properties of this substance have not been fully investigated.

Inhalation

The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 26 36

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Fire Fighting Measures

Flash Point

126

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidants.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2914 50 00