Product Identification

Product Name

Acrivastine

Synonyms

(E)-3-[6-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridin-2-yl]prop-2-enoic acid

CAS

87848-99-5

Formula

C22H24N2O2

Molecular Weight

348.44

Merck

12,129

Physical and Chemical Properties

Solubility in water

Insoluble

Vapor Pressure

3.7E-13 (25 C)

Density

1.17 g/cm3 (20 C)

pKa/pKb

1.99 (pKa)

Partition Coefficient

4.55

Usage

This material is a histamine antagonist (h1 sub-type). It is an agent intended for the treatment of allergic rhinitis.

First Aid Measures

Ingestion

Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation

Physical form suggests that risk of inhalation exposure is negligible.

Skin

Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eyes

Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

Handling and Storage

Storage

No storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

Exposure Controls/Personal Protection

Personal Protection

Wear approved safety glasses with side shields if eye contact is possible.

Exposure Effects

Exposure might occur via ingestion; skin; eyes. Possible effects of overexposure in the workplace include: sedation; irritation; swelling; redness; itching; pain.

Accidental Release Measures

Small spills/leaks

Collect and place it in a suitable, properly labeled container for recovery or disposal. Water can be used for clean-up and decontamination operations

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Fire Fighting Measures

Fire Potential

Expected to be non-combustible.