Product Identification

Product Name

N,N-Dimethylcarbamoyl chloride

Synonyms

Chloroformic acid dimethylamide
Dimethylcarbamyl chloride
N,N-Dimethylcarbamoyl chloride

CAS

79-44-7

Formula

C3H6ClNO

Molecular Weight

107.55

EINECS

201-208-6

RTECS

FD4200000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen

Beilstein/Gmelin

878197

Beilstein Reference

4-04-00-00224

EC Index Number

006-041-00-0

EC Class

Carcinogenic Category 2; Toxic; Harmful; Irritant

Physical and Chemical Properties

Appearance

A colorless to yellow liquid with a pungent odor.

Solubility in water

Decomposes

Melting Point

-33

Boiling Point

165

Vapor Pressure

2

Density

1.174 g/cm3 (15 C)

Partition Coefficient

.41

Usage

Chemical intermediate for parasympathomimetic agents, chemical intermediate for pesticides. Former use.

Vapor Density

3.73

Refractive Index

1.44904 (22.1 C)

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Changes in breathing pattern, irritation, changes in pulmonary function, corrosion and edema of the respiratory tract, chronic bronchitis and noncardiogenic pulmonary edema have been observed.

Skin

Burns, ulceration, scarring, blanching, and irritation may occur.

Eyes

Dental discoloration or erosion, bleeding gums, corneal necrosis, inflammation of the eye, eye and nasal irritation, nasal ulceration, nose bleeds, throat irritation and ulceration have been observed.

Ingestion

Gastritis, burns, gastric hemorrhage, dilation, edema, necrosis, and strictures may occur.

Hazards

Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 45 22 23 36/37/38

EC Safety Phrase

S 53 45

UN (DOT)

2262

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate clothing to prevent any reasonable probability of skin contact. Wear eye protection to prevent any possibility of eye contact.

Respirators

Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.

Exposure Effects

Shock, rapid breathing and pulse, circulatory collapse and other changes to pulse, blood pressure, and respirations may occur. Fetotoxicity, developmental abnormalities, and possible resistance to hydrogen chloride by inhalation during pregnancy have been noted. <br>No data were available on the possible effects of hydrogen chloride exposure during lactation. <br>No information about possible male reproductive effects was found in available references.

Exposure limit(s)

NIOSH REL: Ca See Appendix A

Poison Class

1*

Fire Fighting Measures

Flash Point

68

Fire Fighting

Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary.

Stability and Reactivity

Incompatibilities

Incompatible with strong oxidizing agents, alcohols, bases (including amines) May react vigorously or explosively

Stability

Rapidly hydrolyzes in water to dimethylamine, carbon dioxide and hydrochloric acid; its half-life @ 0 C is about 6 min. Sensitive to moisture.

Decomposition

Dangerous when heated to decomposition it emits very toxic fumes of hydrogen chloride and nitrogen oxides. Decomposes in water.

Combustion Products

Toxic fumes of NOx and HCl

Transport Information

UN Number

2262

Hazard Class

8

Packing Group

II