Product Identification

Product Name

Papaverine hydrochloride

Synonyms

1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
1,1-Dimethylethyl azidoformate
6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
BOC-azide
Carbonazidic acid, 1,1-dimethylethyl ester
Cardiospan
Formic acid, azido-, tert-butyl ester
Papaverine hydrochloride
tert-Butyl azidoformate
tert-Butyloxycarbonyl azide
Vasospan

CAS

1070-19-5

CAS

61-25-6

Formula

C20H22ClNO4

Formula

C5H9N3O2

Molecular Weight

143.15

Molecular Weight

375.88

EINECS

200-502-1

EINECS

213-972-8

RTECS

NW8575000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Beilstein/Gmelin

1363586

Beilstein/Gmelin

3921435

Beilstein Reference

4-03-00-00254

Beilstein Reference

5-21-06-00182

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Freely soluble

Melting Point

220-225

Boiling Point

73 - 76 (70 torr)

Density

1.312 g/cm3

Usage

Vasodilaor. Improves blood circulation. Approved to treat erectile dysfunction.

Refractive Index

1.423 (22 C)

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion

See Inhalation.

Inhalation

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.

Skin

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.

Eyes

See Inhalation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate safety goggles, protective clothing and gloves.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Fire Fighting Measures

Fire Fighting

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or halon extinguisher.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Incompatibilities

Sensitive to light.

Stability

Stable under normal temperatures and pressures.

Decomposition

Upon decomposition, this material can produce hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, and nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Hazard Class

Forbidden

Packing Group

I; II; III