Product Identification

Product Name

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone

Synonyms

4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Aloperidin
Aloperidolo
Aloperidon
gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone

CAS

52-86-8

Formula

C21H23ClFNO2

Molecular Weight

375.87

EINECS

200-155-6

RTECS

EU1575000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,4629

Beilstein/Gmelin

331267

Beilstein Reference

5-21-02-00377

Physical and Chemical Properties

Appearance

Clear, colorless solution with no odor.

Solubility in water

14 mg/L

Melting Point

147

Boiling Point

529

Vapor Pressure

5E-12 (25 C)

Density

1.3 g/cm3 (20 C)

pKa/pKb

5.75 (pKb)

Partition Coefficient

3.36

Heat Of Vaporization

84.6 kJ/mol

Usage

Medication (vet).

First Aid Measures

Ingestion

Wash mouth out with water. Seek medical aid.

Inhalation

Remove to fresh air. Seek medical aid.

Skin

Flush skin with water. Seek medical aid.

Eyes

Flush eyes with water. Seek medical aid.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Exposure Controls/Personal Protection

Personal Protection

Latex gloves, safety goggles, disposable protective apparel.

Respirators

NIOSH approved respirator.

Exposure Effects

Abnormally low blood pressure may develop in adults and children who have ingested an overdose of haloperidol. One pediatric case of elevated blood pressure following overdose has been reported. Elevated body temperature has both been associated with haloperidol therapy and may occur with overdose. Respiratory depression may occur. haloperidol - severe extrapyramidal effects may follow overdose. Irreversible tardive dyskinesia has been reported with therapeutic use and may occur with overdose. Seizures have been reported with pediatric overdose. Neuroleptic malignant syndrome has been rarely reported in adults and children. Droperidol - extrapyramidal effects have been reported following droperidol therapy. Neuroleptic malignant syndrome has been reported in adults and children.

Fire Fighting Measures

Flash Point

274

Fire Fighting

Wear SCBA and protective clothing. Use extinguishing media most appropriate for surrounding fire.

Accidental Release Measures

Small spills/leaks

Wear recommended protective equipment. Sweep up material or absorb with paper towels. Place in appropriate container for disposal.

Stability and Reactivity

Stability

Stable at normal temperature and pressure.