Product Identification

Product Name

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Synonyms

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Azaleptine
Clorazil
Clozaril
Iprox
Leponex

CAS

5786-21-0

Formula

C18H19ClN4

Molecular Weight

326.83

EINECS

227-313-7

RTECS

HP1750000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,2484

Beilstein/Gmelin

764984

Beilstein Reference

5-25-11-00364

Physical and Chemical Properties

Appearance

Yellow crystals from acetone-petroleum ether.

Solubility in water

Insoluble

Melting Point

182

Boiling Point

489

Vapor Pressure

1E-9 (25 C)

pKa/pKb

7.67 (pKb)

Heat Of Vaporization

75.5 kJ/mol

Usage

Atypical antipsychotic compound. Selective antagonist for d4-dopamine receptor. Antagonist at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6, and 5-ht7serotonin receptors.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.

Skin

Causes skin irritation. May be harmful if absorbed through the skin.

Eyes

Causes eye irritation.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22 36/37/38

EC Safety Phrase

26

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

Fire Fighting Measures

Flash Point

250

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable at normal temperatures and pressures.