Product Identification

Product Name

Cyproheptadine

Synonyms

1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine
1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine
1-Phenylethanone
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
Acetylbenzene
Cyproheptadine
Methyl phenyl ketone
Phenyl methyl ketone
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-

CAS

129-03-3

CAS

98-86-2

Formula

C21H21N

Formula

C8H8O

Molecular Weight

120.15

Molecular Weight

287.39999999999998

EINECS

202-708-7

EINECS

204-928-9

RTECS

AM5250000

RTECS

TM7000000

RTECS Class

Mutagen; Primary Irritant

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,2842

Merck

13,74

Beilstein/Gmelin

1685976

Beilstein/Gmelin

605842

Beilstein Reference

4-07-00-00619

Beilstein Reference

5-20-08-00500

EC Index Number

606-042-00-1

EC Class

Harmful; Irritant

Physical and Chemical Properties

Appearance

Colorless liquid, sweet, almond odor.

Appearance

Crystals from dil ethanol.

Solubility in water

5.5 g/L

Solubility in water

Insoluble

Melting Point

116.5 - 118

Melting Point

20

Boiling Point

201.7

Vapor Pressure

0.3 (25 C)

Density

1.027 g/cm3 (20 C)

pKa/pKb

5.30 (pKb)

Partition Coefficient

1.58

Heat Of Vaporization

49.0 kJ/mol

Usage

Medication.

Usage

In perfumery to impart an orange-blossom-like odor, catalyst for polymerization of olefins, in organic synthesis, esp as photosensitizer.

Saturation Concentration

Approximately 1300 ppm (0.13%) at 20 C (calculated)

Odor threshold

0.01-0.025 mg/m3

Refractive Index

1.5339 (20 C)

First Aid Measures

Ingestion

Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Inhalation

Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Skin

Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.

Skin

Causes skin irritation.

Eyes

May cause transient corneal injury. Causes severe eye irritation and possible injury.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Keep away from heat and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Storage

Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a well-closed container.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Pneumonitis, chest tightness, and wheezing have been reported.

Skin

Skin may be flushed, warm and dry after overdose.

Eyes

Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use.

Ingestion

Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur .

Hazards

Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.

EC Risk Phrase

R 22 36

EC Safety Phrase

S 26

UN (DOT)

1993

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. Laboratory experiments have resulted in mutagenic effects. Narcotic in high concentrations.

Exposure Effects

Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk.

Exposure limit(s)

TLV: 10 ppm; 49 mg/m3 (ACGIH 1993-1994).

Poison Class

4

Fire Fighting Measures

Flash Point

82

Autoignition

570

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Upper exp. limit

5.2

Lower exp. limit

1.4

Fire Potential

Slight when exposed to head or flame.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

Relatively stable in light, stable @ room temperature.

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong bases, strong reducing agents, aldehydes, nitric acid + hydrogen peroxide, perchloric acid.

Incompatibilities

Strong oxidizing agents.

Disposal Code

3

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1993

Hazard Class

3

Packing Group

I; II; III

HS Code

2914 39 00