Product Identification

Product Name

1,1'-Methylenebis(4-isocyanatobenzene)

Synonyms

IMO Pollution Category
4,4-Diisocyanodiphenylmethane
Isonate
MDI
Methylene bis(4-phenyl isocyanate)
Methylene bisphenyl diisocyanate

CAS

101-68-8

Formula

C15H10N2O2

Molecular Weight

250.26

EINECS

202-966-0

RTECS

NQ9350000

RTECS Class

Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Beilstein/Gmelin

797662

Beilstein Reference

4-13-00-00396

EC Index Number

615-005-00-9

EC Class

Harmful; Irritant; Sensitising

Physical and Chemical Properties

Appearance

White to pale yellow solid. May have slightly musty odor. Liquid above 38 deg c. Often shipped and stored in melted state for improved stability.

Solubility in water

2 g/L (20 C)

Melting Point

37 - 38

Boiling Point

373

Vapor Pressure

1E-5 (25 C)

Density

1.318 g/cm3 (20 C)

Partition Coefficient

4.94

Heat Of Vaporization

62.1 kJ/mol

Usage

Adhesives, coatings manufacture, elastomers, flexible foam, rigid foam.

Vapor Density

8.6

Saturation Concentration

0.18 ppm at 25 C (calculated)

Refractive Index

1.5906 (50 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry place. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Refrigerator (approx 4 C).

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause asthmatic attacks due to allergic sensitization of the respiratory tract.

Skin

Causes skin irritation.

Eyes

Causes eye irritation and possible burns.

Ingestion

Causes gastrointestinal tract irritation.

Hazards

Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 20 36/37/38 42/43

EC Safety Phrase

S 23 36/37 45

UN (DOT)

2489

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Prolonged or repeated skin contact may cause sensitization dermatitis and possible destruction and/or ulceration.

Exposure limit(s)

OSHA PEL: C 0.2 mg/m3 (0.02 ppm) NIOSH REL: TWA 0.05 mg/m3 (0.005 ppm) C 0.2 mg/m3 (0.020 ppm) 10-minute NIOSH IDLH: 75 mg/m3

Poison Class

3

Fire Fighting Measures

Flash Point

154

Autoignition

232

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. May ignite or explode on contact with steam or moist air. Containers may explode when heated. Extinguishing media: Use dry sand or earth to smother fire. Use water spray to cool fire-exposed containers. DO NOT USE WATER! Most foams will react with the material and release corrosive/toxic gases. Contact professional fire-fighters immediately. Use dry chemical or carbon dioxide.

Lower exp. limit

.6

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water.

Stability and Reactivity

Disposal Code

1

Incompatibilities

Alcohols, alkalies, acids.

Stability

Stable under normal temperatures and pressures. Combines vigorously or explosively with water.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, cyanide fumes, nitrogen.

Combustion Products

Toxic vapors are generated when heated.

Transport Information

UN Number

2489

Hazard Class

6.1

HS Code

2929 10 90