Product Identification

Product Name

4-Amino-3,5,6-trichloropicolinic acid

Synonyms

4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichloropyridine-2-carboxylic acid

CAS

1918-02-1

Formula

C6H3Cl3N2O2

Molecular Weight

241.46

EINECS

217-636-1

RTECS

TJ7525000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector

Merck

12,7552

Beilstein/Gmelin

479075

Beilstein Reference

5-22-13-00585

Physical and Chemical Properties

Appearance

Fine beige crystals or white powder. Odor of chlorine.

Solubility in water

400 mg/L

Melting Point

218 - 219

Boiling Point

366

Vapor Pressure

.000000616

pKa/pKb

3.6 (pKa)

Partition Coefficient

1.89

Usage

Systemic herbicide.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep containers closed.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Picloram dust is irritating to the respiratory tract.

Skin

Picloram is mildly irritating to skin.

Eyes

Eye irritation may occur with exposure to picloram.

Ingestion

Nausea is possible after ingestion of massive amounts of picloram.

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate eye protection and protective clothing to prevent skin and eye contact.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Although seizures have not been reported in humans, seizures have developed in animals exposed to fatal amounts. No teratogenicity was observed in several studies. However, there are reports that Tordon 202c (a picloram and 2,4-D combination herbicide) showed teratogenesis and fetal growth depression in mice by paternal exposure and combined preconceptional and gestational exposure.

Exposure limit(s)

TLV: ppm; 10 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 15 mg/m3 (total) TWA 5 mg/m3 (resp) NIOSH REL: See Appendix D

Poison Class

4

Fire Fighting Measures

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

Low volatility storage Stability: A minimum of 2 years the expected shelf life of concentrated chemical is approximately three years in aqueous solution, decomposed by UV irradiation.

Incompatibilities

May be sensitive to prolonged exposure to light Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.