Product Identification

Product Name

alpha-Ayridylamine

Synonyms

2-Pyridinamine
2-Pyridylamine
alpha-Aminopyridine
o-Aminopyridine
Pyridin-2-amine

CAS

504-29-0

Formula

C5H6N2

Molecular Weight

94.12

EINECS

207-988-4

RTECS

US1575000

RTECS Class

Human Data

Merck

13,472

Beilstein/Gmelin

105785

Beilstein Reference

5-22-08-00280

EC Class

toxic, irritant

Physical and Chemical Properties

Appearance

Colorless crystalline solid, characteristic, unpleasant odor, white leaflets or large colorless crystals, white powder or crystals.

Solubility in water

Highly soluble

Melting Point

50 - 52

Boiling Point

210.6

Vapor Pressure

0.2 (25 C)

Density

1.24 g/cm3

pKa/pKb

7.20 (pKb)

Partition Coefficient

.48

Heat Of Vaporization

52.75 kJ/mol

Heat Of Combustion

-2856 kJ/mol

Usage

Intermediate in chemical synthesis.

Vapor Density

3.25

Saturation Concentration

1053 ppm (0.10%) (calculated)

Refractive Index

1.56552 (65 C)

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.

Hazards Identification

Inhalation

Causes respiratory tract irritation. May cause severe headaches, nausea, increased blood pressure, weakness, convulsions, and a stuporous state.

Skin

Causes skin irritation. May be fatal if absorbed through the skin. Substance is rapidly absorbed through the skin. Causes symptoms similar to those of inhalation. Causes redness and pain.

Eyes

Causes eye irritation. Causes redness and pain.

Ingestion

May be fatal if swallowed. May cause irritation of the digestive tract. Poison by ingestion. May cause effects similar to those for inhalation exposure. An oral dose of 590 mg/kg of 4-aminopyridine in a man produced shortness of breath, nausea, vomiting, hallucinations and distorted perception. Affects the CNS to produce tremor, excitability and convulsions.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 21 23/25 33 36/37/38

EC Safety Phrase

S 26 36/37/39 45

UN (DOT)

2671

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Weakness, dizziness, disorientation, hyperexcitibility, tremors, periorbital paresthesias and tonic-clonic seizures may be noted.

Exposure limit(s)

TLV: 0.5 ppm; 1.9 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 0.5 ppm (2 mg/m3) NIOSH REL: TWA 0.5 ppm (2 mg/m3) NIOSH IDLH: 5 ppm

Poison Class

2

Fire Fighting Measures

Flash Point

93

Autoignition

> 630

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Combustible solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Oxidizing agents, strong acids, acid chlorides, acid anhydrides

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in a fire involving 2-aminopyridine.

Transport Information

UN Number

2671

Hazard Class

6.1

Packing Group

II

HS Code

2933 39 99