Product Identification

Product Name

S-2-Hydroxymethyl-pyrrolidine

Synonyms

(2S)-2-(Hydroxymethyl)pyrrolidine
(2S)-2-Pyrrolidinemethanol
[(2S)-Pyrrolidin-2-yl]methanol
2-Pyrrolidinemethanol, (S)-
L-(Pyrrolidin-1-yl)methanol
L-2-(Hydroxymethyl)pyrrolidine

CAS

23356-96-9

Formula

C5H11NO

Molecular Weight

101.14

EINECS

245-605-2

Beilstein/Gmelin

79843

Beilstein Reference

5-21-01-00077

Physical and Chemical Properties

Appearance

Colorless viscous liquid.

Solubility in water

Very soluble

Boiling Point

75

Density

1.025 g/cm3

pKa/pKb

3.44 (pKb)

Usage

Used as a chiral building block in organic synthesis.

Vapor Density

3.49

Refractive Index

1.4878 (20 C)

First Aid Measures

Ingestion

Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Do not expose to air. Store protected from moisture. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Inhalation

Causes respiratory tract irritation. Aspiration may lead to pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.

Skin

Causes skin irritation. May cause irritation and dermatitis. May cause cyanosis of the extremities.

Eyes

Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

EC Risk Phrase

R 36/38

EC Safety Phrase

S 26 36

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

86

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Place under an inert atmosphere.

Stability and Reactivity

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Incompatibilities

Strong oxidizing agents, acid chlorides, acid anhydrides, moisture, air.

Decomposition

Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.