Product Identification

Product Name

5-Fluoropyrimidine-2,4-dione

Synonyms

5-Fluoro-1H-pyrimidine-2,4-dione
5-Fluoro-2,4(1H,3H)-pyrimidinedione

CAS

51-21-8

Formula

C4H3FN2O2

Molecular Weight

130.08000000000001

EINECS

200-085-6

RTECS

YR0350000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

13,4208

Beilstein/Gmelin

127172

Beilstein Reference

5-34-06-00271

EC Class

harmful

Physical and Chemical Properties

Appearance

White to nearly white crystalline powder; practically odorless.

Solubility in water

Very soluble

Melting Point

282 - 283

Boiling Point

347

pKa/pKb

7.88 (pKa)

Partition Coefficient

-.78

Heat Of Vaporization

Usage

Immunosuppressive agent.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Store protected from light. Use only in a chemical fume hood.

Hazards Identification

Inhalation

Harmful if inhaled. Causes respiratory tract irritation.

Skin

Causes skin irritation. Harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.

Hazards

Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat.

EC Risk Phrase

R 46 60 61 23/24/25

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron.

Respirators

A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.

Exposure Effects

Prolonged or repeated exposure may cause adverse reproductive effects.

Poison Class

1*

Fire Fighting Measures

Flash Point

280

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use water spray, dry chemical, or carbon dioxide.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride.

Transport Information

UN Number

2811

HS Code

2933 59 95