Product Identification

Product Name

Fomepizol

Synonyms

4-Methyl-1H-pyrazole
4-Methylpyrazole
4-MP
Fomepizole

CAS

7554-65-6

Formula

C4H6N2

Molecular Weight

82.1

EINECS

231-445-0

RTECS

UQ7350000

RTECS Class

Other

Merck

13,4242

Beilstein/Gmelin

105204

Beilstein Reference

5-23-05-00031

Physical and Chemical Properties

Appearance

Yellow liquid.

Solubility in water

Soluble

Melting Point

16 - 19

Boiling Point

244

Vapor Pressure

0.05 (25 C)

Density

1.0183 g/cm3 (17 C)

pKa/pKb

10.79 (pKb)

Partition Coefficient

.78

Heat Of Vaporization

46.1 kJ/mol

Usage

Antidot for ethylene glycol poisoning treatment.

Vapor Density

2.83

Refractive Index

1.4895 (16.7 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.

Hazards Identification

Ingestion

Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

EC Risk Phrase

R 22 36/37/38

EC Safety Phrase

S 26 36/37/39

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Fire Fighting Measures

Flash Point

96

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents - strong acids - acid chlorides.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.