Product Identification

Product Name

Hydroxyurea

Synonyms

Hydroxycarbamide

CAS

127-07-1

Formula

CH4N2O2

Molecular Weight

76.06

EINECS

204-821-7

RTECS

YT4900000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

13,4874

Beilstein/Gmelin

1741548

Beilstein Reference

4-03-00-00170

Physical and Chemical Properties

Appearance

Odorless or almost odorless white to off-white crystalline solid. Tasteless.

Solubility in water

Soluble

Melting Point

142 - 144

Boiling Point

296

Partition Coefficient

-1.8

Usage

Medication.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Inhalation of dust may cause respiratory tract irritation.

Skin

May cause skin irritation. May cause dermatitis.

Eyes

May cause eye irritation.

Ingestion

May cause bone marrow depression. Ingestion of large amounts may cause nausea and vomiting, which can produce dehydration, internal organ congestion and possibly coma. May cause microcytosis (smaller than normal red blood cells), normocytic anemia (reduced red blood cell count), luekopenia(reduced white blood cell count), thrombocytopenia (decreased number of blood platelets) and other blood abnormalities.

EC Risk Phrase

R 46 61

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Hydroxyurea crosses the placenta in animals, and is embryotoxic.

Poison Class

1*

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Transport Information

UN Number

2811