Product Identification

Product Name

Tosyl isocyanate

Synonyms

4-Isocyanatosulphonyltoluene
Benzenesulfonyl isocyanate, 4-methyl
Tosyl isocyanate

CAS

4083-64-1

Formula

C8H7NO3S

Molecular Weight

197.22

EINECS

223-810-8

RTECS

DB9032000

RTECS Class

Primary Irritant

Beilstein/Gmelin

391287

Beilstein Reference

4-11-00-00402

EC Index Number

615-012-00-7

EC Class

Reacts violently with water; Irritant; Sensitising

Physical and Chemical Properties

Appearance

Clear, colorless liquid.

Solubility in water

Insoluble

Melting Point

5

Boiling Point

288

Vapor Pressure

0.004 (25 C)

Density

1.295 g/cm3 (20 C)

Partition Coefficient

2.44

Heat Of Vaporization

50.7 kJ/mol

Vapor Density

6.8

Refractive Index

1.53 (20 C)

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water.

Handling

Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not allow contact with water. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Causes respiratory tract irritation. Can produce delayed pulmonary edema. May cause respiratory sensitization.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist.

Eyes

Causes eye irritation. Lachrymator. When substances becomes wet or comes in contact with moisture of the mucous membranes, it becomes an irritant. May cause chemical conjunctivitis.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.

EC Risk Phrase

R 14 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39

UN (DOT)

2206

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed.

Poison Class

2

Fire Fighting Measures

Flash Point

128

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. May ignite or explode on contact with steam or moist air. Extinguishing media: Use dry sand or earth to smother fire. Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Contact professional fire-fighters immediately.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not expose spill to water.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures. Combines vigorously or explosively with water.

Incompatibilities

Water, alcohols, amines, acids, strong bases, strong oxidizing agents.

Decomposition

Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2206

Hazard Class

6.1

Packing Group

II; III