Product Identification

Product Name

Isonicotinamide

Synonyms

4-Carbamoylpyridine
4-Pyridinecarboxamide
gamma-Pyridinecarboxamide
Isonicotinic acid amide
Pyridine-4-carboxamide

CAS

1453-82-3

Formula

C6H6N2O

Molecular Weight

122.13

EINECS

215-926-2

RTECS

NR9500000

RTECS Class

Mutagen

Beilstein/Gmelin

2173

Beilstein Reference

5-22-02-00195

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Soluble

Melting Point

155 - 157

Boiling Point

334

Vapor Pressure

0.00013 (25 C)

pKa/pKb

10.61 (pKa)

Partition Coefficient

-.52

Heat Of Vaporization

57.7 kJ/mol

Heat Of Combustion

-3068 kJ/mol

Vapor Density

4.21

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation.

Hazards Identification

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed.

Fire Fighting Measures

Flash Point

156

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Incompatibilities

Strong oxidizing agents, strong bases.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Transport Information

HS Code

2933 39 99