Product Identification

Product Name

4-Hydroxy-3-methoxybenzaldehyde

Synonyms

4-Formyl-2-methoxyphenol
4-Hydroxy-3-methoxybenzaldehyde
p-Hydroxy-m-methoxybenzaldehyde
Rhovanil
Vanillaldehyde
Vanillic aldehyde

CAS

121-33-5

Formula

C8H8O3

Molecular Weight

152.15

EINECS

204-465-2

RTECS

YW5775000

RTECS Class

Mutagen; Reproductive Effector; Natural Product

Merck

12,10069

Beilstein/Gmelin

472792

Beilstein Reference

4-08-00-01763

Physical and Chemical Properties

Appearance

White or very slightly yellow needles.

Solubility in water

10 g/L

Melting Point

82

Boiling Point

285

Vapor Pressure

0.0019 (25 C)

Density

1.056 g/cm3 (20 C)

pKa/pKb

7.78 (pKa)

Partition Coefficient

1.37

Heat Of Vaporization

54.3 kJ/mol

Heat Of Combustion

-1850 kJ/mol

Usage

Flavoring agent in galenicals, in perfumery, reagent in analytical chemistry, pharmaceutic aid (flavor).

Vapor Density

5.2

Refractive Index

1.555

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Treat symptomatically and supportively. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store protected from moisture. Store protected from light.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Store protected from light.

Hazards Identification

Ingestion

May cause irritation of the digestive tract.

Inhalation

No hazard expected in normal industrial use. Dust is irritating to the respiratory tract.

Skin

Dust may cause mechanical irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Low hazard for usual industrial handling.

Eyes

Dust may cause mechanical irritation. Low hazard for normal industrial handling.

EC Risk Phrase

R 22

EC Safety Phrase

S 22 36/37

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure limit(s)

OSHA Permissible Exposure Limit (PEL): 15 mg/m3 total dust, 5 mg/m3 respirable fraction for nuisance dusts.

Poison Class

4

Fire Fighting Measures

Flash Point

118

Autoignition

> 400

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Upper exp. limit

8.8

Lower exp. limit

1.2

Fire Potential

Flammability properties of some synthetic fragrant substances and intermediate products.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong bases, light, air, strong reducing agents, moisture, bromine, perchloric acid, potassium t-butoxide, t-chlorobenzene and sodium hydroxide, formic acid and thallium nitrate.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2912 41 00