Product Identification

Product Name

Etoposide

Synonyms

(-)-Etoposide, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)
9-((4,6-O-Ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
Lastet
Toposar
VePesid

CAS

33419-42-0

Formula

C29H32O13

Molecular Weight

588.57000000000005

EINECS

251-509-1

RTECS

KC0190000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,3931

Beilstein/Gmelin

3659695

Physical and Chemical Properties

Appearance

Typically in the form of pink, liquid fillled, soft gelatin capsules.

Solubility in water

approx 0.08 mg/ml

Melting Point

262 - 263

pKa/pKb

9.8(at 25℃) (pKa)

Usage

Medication.

First Aid Measures

Ingestion

Seek immediate medial attention.

Inhalation

Seek immediate medial attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Store under refrigeration, in orginal container.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Dyspnea, acute bronchospasm, apnea and cyanosis have been reported. Fatal pulmonary toxicity has been reported after oral use.

Skin

Rash, urticaria and/or pruritus have been infrequently reported. Erythema and desquamation, alopecia, onycholysis, and stevens-johnson syndrome have occurred following therapeutic use of etoposide.

Eyes

Conjunctivitis.

Ingestion

Ausea, vomiting and diarrhea commonly occur. Paralytic ileus has been reported.

Exposure Controls/Personal Protection

Personal Protection

Surgical latex gloves -- which should be changed regularly. Safety goggles.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Bone marrow supression. Cytotoxic agent. Anaphlactic-like reaction is possible. Possible carcinogen.

Fire Fighting Measures

Fire Fighting

Wear SCBA and full protective clothing. Extinguish fire with water, COT or dry chemical powder.

Accidental Release Measures

Small spills/leaks

Scoop up material and place in container for later disposal.

Stability and Reactivity

Stability

Stable under normal storage and usage conditions. Avoid elevated temperatures.