Product Identification

Product Name

(+)-2-(6-Methoxy-2-naphthyl)-propionic acid

Synonyms

(1)-2-(6-Methoxy-2-naphthyl)propionic acid
2-(6-Methoxynaphthalen-2-yl)propanoic acid
Cg 3117
Diocodal
Dysmenalgit n
Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (S)-

CAS

22204-53-1

Formula

C14H14O3

Molecular Weight

230.26

EINECS

244-838-7

RTECS

UF5275000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,6504

Beilstein/Gmelin

3591067

Physical and Chemical Properties

Appearance

Crystals from acetone-hexane. Practically odorless.

Solubility in water

Insoluble

Melting Point

156

Boiling Point

404

Vapor Pressure

3E-7 (25 C)

pKa/pKb

4.15 (pKa)

Partition Coefficient

3.24

Heat Of Vaporization

69.1 kJ/mol

Usage

Anti-inflammatory drug.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Apnea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing.

Skin

Photosensitivity and pseudoporphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use.

EC Risk Phrase

R 22 36/37/38

EC Safety Phrase

S 26 36/37/39

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen. Naproxen is pregnancy category B. <br>&nbsp;&nbsp;&nbsp;1. Risk Factor D if used in 3rd trimester or near delivery. <br>Because of known effects of the fetus (closure of ductus arteriosus), it should be avoided during late pregnancy. <br>Naproxen has been found in the milk of lactating women; however, The American Academy of Pediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998).

Fire Fighting Measures

Flash Point

155

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.