Product Identification

Product Name

4-Fluorophenyl isocyanate

Synonyms

4-Fluoroisocyanatobenzene
Benzene, 1-fluoro-4-isocyanato-
p-Fluorobenzene isocyanate
p-Fluorophenyl isocyanate

CAS

1195-45-5

Formula

C7H4FNO

Molecular Weight

137.11000000000001

EINECS

214-799-0

Beilstein/Gmelin

471609

Physical and Chemical Properties

Appearance

Clear light amber to yellow liquid.

Solubility in water

Insoluble

Boiling Point

42 - 47 (1 torr)

Density

1.206 g/cm3

Refractive Index

1.51 (20 C)

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Refrigerator/flammables.

Handling

Wash thoroughly after handling. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Inhalation

At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Vapor or mist is irritating to the mucous membranes and upper respiratory tract.

Skin

Causes skin irritation. Organic isocyanates can cause local irritation and allergic reactions.

Eyes

Vapors cause eye irritation. Lachrymator.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by aspyhxiation.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.

EC Risk Phrase

R 10 23/25 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

3080

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Repeated exposure may cause sensitization dermatitis. Repeated exposure may cause allergic respiratory reaction (asthma).

Fire Fighting Measures

Flash Point

52

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Do NOT use water directly on fire. Use carbon dioxide or dry chemical.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, acids, strong bases, alcohols, amines.

Decomposition

Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3080

Hazard Class

6.1

Packing Group

II