Product Identification

Product Name

Erythromycin

Synonyms

(3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)oxacyclotetradecane-2,10-dione
(3R,5R,6S,7R,8R,11R,13R,14R,15S,16R)-7-((2R,3S,4R,6S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-16-ethyl-8,14,15-trihydroxy-5-((2R,4S,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy)-3,6,8,11,13,15-hexamethyloxacyclohexadecane-2,12-dione
Abboticin
Abomacetin
Dotycin
EMU

CAS

114-07-8

Formula

C37H67NO13

Molecular Weight

733.94

EINECS

204-040-1

RTECS

KF4375000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Natural Product

Merck

12,3720

Beilstein/Gmelin

75279

Beilstein Reference

5-18-10-00398

Physical and Chemical Properties

Appearance

Hydrated crystals from water. Odorless or practically odorless.

Solubility in water

about 2 mg/ml

Melting Point

135-140

Density

1.226 g/cm3

pKa/pKb

8.8 (pKb)

Usage

Pharmaceutical.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause allergic respiratory reaction.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

May cause eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Substance may cause liver and blood abnormalities. Allergic reactions and hearing abnormalities have also been

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Vital sign changes, while rare, may include reduced body temperature and abnormally low blood pressure. sensorineural hearing loss may occur in patients receiving treatment with large doses of macrolide antibiotics, especially in patients suffering from concomitant liver and/or kidney disease. The hearing loss is usually reversible upon discontinuation of the drug. Exacerbation of myasthenia gravis may occur infrequently following erythromycin administration. Pyloric stenosis has been associated with the ingestion of erythromycin through breastmilk.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.