Product Identification

Product Name

4-Methylaniline

Synonyms

4-Amino-1-methylbenzene
4-Aminotoluene
p-Methylaniline

CAS

106-49-0

Formula

C7H9N

Molecular Weight

107.16

EINECS

203-403-1

RTECS

XU3150000

RTECS Class

Mutagen; Primary Irritant

Merck

12,9674

Beilstein/Gmelin

471281

Beilstein Reference

4-12-00-01866

EC Index Number

612-160-00-4

EC Class

Carcinogenic Category 3; Toxic; Irritant; Sensitising; Dangerous for the Environment

Physical and Chemical Properties

Appearance

Colorless solid. May be absorbed through the skin.

Solubility in water

7 g/L

Melting Point

43

Boiling Point

201

Vapor Pressure

1-.38 (25 C)

Density

1.046 g/cm3 (20 C)

pKa/pKb

8.9 (pKb6)

Partition Coefficient

1.4

Heat Of Vaporization

43.4 kJ/mol

Heat Of Combustion

-2954 kJ/mol

Usage

Dyes, organic synthesis, reagent for lignin, nitrite, chloroglucinol.

Vapor Density

3.9

Refractive Index

1.5534 (45 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.

Handling

Wash thoroughly after handling. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Inhalation

May be fatal if inhaled. May cause drowsiness, unconsciousness, and central nervous system depression. Inhalation causes anoxia due to the formation of methemoglobin and hematuria. Inhalation may lead to dizziness, weakness, and drowsiness, leading to stupor, unconsciousness, and even death. Inhalation may produce headache and cyanosis of the lips, the mucous membranes, and the fingernail beds, and the tongue.

Skin

Causes skin irritation. Harmful if absorbed through the skin.

Eyes

Causes eye irritation.

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 23/24/25 36 40 43 50

EC Safety Phrase

S 28 36/37 45 61

UN (DOT)

1708

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic inhalation may cause effects similar to those of acute inhalation. May cause cancer in humans. Chronic exposure leads to anemia, anorexia, weight loss, and cutaneous lesions.

Exposure limit(s)

NIOSH REL: Ca See Appendix A

Poison Class

1*

Fire Fighting Measures

Flash Point

87

Autoignition

482

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Combustible solid. May react with metals and lead to the formation of flammable hydrogen gas. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.

Upper exp. limit

7.6

Lower exp. limit

1.2

Fire Potential

Flammable when exposed to heat, flame, or oxidizers.

Accidental Release Measures

Small spills/leaks

Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition.

Stability and Reactivity

Disposal Code

9

Incompatibilities

Aromatic amines, strong acids, oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Toxic and flammable vapors may form in fire.

Transport Information

UN Number

1708

Hazard Class

6.1

Packing Group

II

HS Code

3822 00 00