Product Identification

Product Name

Isocyanatocyclohexane

Synonyms

Isocyanatocyclohexane

CAS

3173-53-3

Formula

C7H11NO

Molecular Weight

125.17

EINECS

221-639-3

RTECS

NQ8650000

RTECS Class

Mutagen

Beilstein/Gmelin

507983

Beilstein Reference

4-12-00-00071

EC Class

flammable, very toxic, corrosive, sensitizing, da

Physical and Chemical Properties

Appearance

Colorless to pale yellow liquid, lachrymator.

Solubility in water

Insoluble

Melting Point

-80

Boiling Point

169

Vapor Pressure

21.6 (25 C)

Density

0.980 g/cm3 (20 C)

Partition Coefficient

2.89

Heat Of Vaporization

48.9 kJ/mol

Usage

Used to make pharmaceuticals and agricultural chemicals.

Vapor Density

4.3

Saturation Concentration

Approximately 2600 ppm (0.26%) at 25 C (calculated)

Refractive Index

1.4551 (20 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Handling and Storage

Storage

Keep away from sources of ignition. Store in a tightly closed container. Refrigerator/flammables. Store protected from moisture.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not allow contact with water. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Exposure produces central nervous system depression. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Exposure to low and often even unmeasurable isocyanate concentration results in sensitization. May cause burning sensation in the chest.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause irritation and dermatitis. May cause cyanosis of the extremities.

Eyes

Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator. May cause conjunctivitis, ulceration and turbidity of the cornea.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Ingestion of large amounts may cause CNS depression.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

EC Risk Phrase

R 10 23 22 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

2488

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause liver and kidney damage. Effects may be delayed. May cause lung damage. Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Inhalation of product may aggravate existing chronic repiratory problems such as asthma, emphysema or bronchitis.

Fire Fighting Measures

Flash Point

49

Autoignition

390

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Runoff from fire control or dilution water may cause pollution. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water.

Upper exp. limit

8.6

Lower exp. limit

1.1

Fire Potential

HIGHLY FLAMMABLE.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors.

Stability and Reactivity

Disposal Code

9

Incompatibilities

Moisture, acids, alcohols, amines, heat, strong oxidizing agents, strong bases.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen, hydrocarbons.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2488

Hazard Class

6.1

Packing Group

I

HS Code

2929 10 90