Product Identification

Product Name

PGE2

Synonyms

7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
7-(3-HydroxyProsta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
Cerviprost
Dinoprostone
Glandin
Minprositin E2

CAS

363-24-6

Formula

C20H32O5

Molecular Weight

352.47

EINECS

206-656-6

RTECS

UK8000000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Hormone

Merck

12,8064

Beilstein/Gmelin

2224724

Physical and Chemical Properties

Appearance

White crystals.

Solubility in water

Slightly soluble

Melting Point

70

Density

1.114 g/cm3

pKa/pKb

4.76 (pKa)

Usage

Induction of labor.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Keep container closed when not in use. Deep freeze (below -20 C). Store protected from light. Store with dessicant.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood.

Hazards Identification

Inhalation

The toxicological properties of this substance have not been fully investigated. May cause irritation of the mucous membranes.

Skin

May cause skin irritation. The toxicological properties of this material have not been fully investigated.

Eyes

May cause eye irritation. The toxicological properties of this material have not been fully investigated.

Ingestion

Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Other effects include headache, flushing, shivering and dizziness.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Chronic exposure may cause reproductive disorders and teratogenic effects. May cause termination of pregnancy.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Acids, bases.

Stability

Stable under normal temperatures and pressures. Light sensitive.

Decomposition

Carbon monoxide, carbon dioxide, acrid smoke and fumes.