Product Identification

Product Name

18-beta-Glycyrrhetinic acid

Synonyms

Arthrodont
Enoxolone
Glycyrrhetin
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)-
Subglycyrrhelinic acid
Uralenic acid

CAS

471-53-4

Formula

C30H46O4

Molecular Weight

470.69

EINECS

207-444-6

RTECS

RK0180000

RTECS Class

Other

Merck

12,3628

Beilstein/Gmelin

2229654

Beilstein Reference

4-10-00-03775

Physical and Chemical Properties

Appearance

White to gray white solid.

Solubility in water

Insoluble

Melting Point

327 - 330

pKa/pKb

4.71 (pKa)

Usage

Expectorant and antitussive.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container. Refrigerator (approx 4 C).

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed.

Inhalation

May cause respiratory tract irritation. May be harmful if inhaled.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Poison Class

4

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong acids, strong bases, oxygen.

Decomposition

Carbon monoxide, carbon dioxide.