Product Identification

Product Name

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid

Synonyms

Aristolochic acid 1
Aristolochic acid A
Aristolochic acid I
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-
Tardolyt
TR 1736

CAS

313-67-7

Formula

C17H11NO7

Molecular Weight

341.27

EINECS

206-238-3

RTECS

CF3325000

RTECS Class

Tumorigen; Drug; Mutagen; Human Data; Natural Product

Merck

12,822

Beilstein/Gmelin

345159

Beilstein Reference

5-19-07-00611

Physical and Chemical Properties

Appearance

Orange-yellow powder.

Solubility in water

Slightly soluble

Density

1.499 g/cm3

pKa/pKb

3.18 (pKa)

Partition Coefficient

2.79

Usage

Contained in a number of botanical products sold as traditional medicines or as dietary supplements or weight-loss remedies. It’s use can cause permanent kidney damage and cancer.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.

Handling

Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract. May cause kidney damage. Human fatalities have been reported from acute poisoning.

UN (DOT)

1544

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Prolonged or repeated skin contact may cause dermatitis. May cause kidney damage.

Poison Class

2

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Non-Combustible

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1544

Hazard Class

6.1

Packing Group

I; II; III