Product Identification

Product Name

Cyclophosphamide

Synonyms

2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide
Cytoxan
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
Procytox

CAS

50-18-0

Formula

C7H15Cl2N2O2P

Molecular Weight

261.08999999999997

EINECS

200-015-4

RTECS

RP5950000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,2816

Beilstein/Gmelin

11744

Beilstein Reference

4-27-00-09750

Physical and Chemical Properties

Appearance

Fine white crystalline powder. Odorless with a slightly bitter taste.

Solubility in water

40 g/L

Melting Point

65 - 66

Boiling Point

336

Vapor Pressure

0.0001 (25 C)

Density

1.479 g/cm3

pKa/pKb

9.91 (pKb)

Partition Coefficient

.63

Heat Of Vaporization

57.9 kJ/mol

Usage

Medication. Myeloablative agonist.

First Aid Measures

Ingestion

If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Preserve in tight containers between 2 and 32 C.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Pneumonitis or interstitial pulmonary fibrosis may occur.

Skin

Extravasation does not produce a local reaction. Alopecia, pigmentation of finger nails and skin may occur.

Eyes

Flushing of the face may occur. Swollen lips may be noted.

Ingestion

Nausea, vomiting, diarrhea, stomatitis, and hemorrhagic colitis have been reported.

UN (DOT)

1851

Exposure Controls/Personal Protection

Personal Protection

If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Exposure Effects

Agitation, dizziness, tiredness, weakness, and headache may occur. Not recommended in pregnancy or breast-feeding.

Fire Fighting Measures

Flash Point

157

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

Aq solution keeps for a few hr @ room temperature, but hydrolysis occurs above 30 C, removes chlorine atoms; darkens on exposure to light monohydrate sensitive to oxidation, moisture. Monohydrate.

Incompatibilities

Sensitive to exposure to light (darkens) Sensitive to oxidation Incompatible with benzyl alcohol.

Transport Information

UN Number

1851