Product Identification

Product Name

Doxycycline

Synonyms

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
6-Deoxy-5-hydroxytetracycline
6-Deoxytetracycline
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
Doxycyclin hyclate

CAS

564-25-0

Formula

C22H24N2O8

Molecular Weight

444.44

EINECS

209-271-1

RTECS

QI8650000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,3496

Beilstein/Gmelin

2230419

Physical and Chemical Properties

Appearance

Yellow, crystalline powder with slight ethanolic odor.

Solubility in water

Slightly soluble

Vapor Pressure

2E-24 (25 C)

pKa/pKb

4.50 (pKa)

Partition Coefficient

-.26

Usage

Medication.

First Aid Measures

Ingestion

Flush mouth out with water. Seek medical attention.

Inhalation

Remove to fresh air.

Skin

Flush with copious amounts of water for at least 15 minutes.

Eyes

Flush with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage

store in a tightly closed container.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Allergic reaction. Irritation.

Skin

Skin hyperpigmentation has been reported.

Eyes

Irritation.

Ingestion

Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon.

Exposure Controls/Personal Protection

Personal Protection

Rubber or vinyl gloves, safety goggles and appropriate laboratory clothings.

Respirators

NIOSH approved respirator.

Exposure Effects

Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy.

Fire Fighting Measures

Fire Fighting

Evacuate area. Wear SCBA and protective clothing. Use agent most suitable for extinguishing surrounding fire.

Accidental Release Measures

Small spills/leaks

Wear dust respirator and rubber gloves. Sweep up, avoiding dust generation. Place in appropriate container for disposal.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Toxic fumes.