Product Identification

Product Name

1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile

Synonyms

1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
WIN-47203
YM-018

CAS

78415-72-2

Formula

C12H9N3O

Molecular Weight

211.22

EINECS

278-903-6

RTECS

DW1762000

RTECS Class

Drug

Merck

12,6284

Beilstein/Gmelin

3546821

Beilstein Reference

6-25

Physical and Chemical Properties

Appearance

white solid

Solubility in water

Insoluble

Melting Point

313 - 316

Boiling Point

449

Vapor Pressure

3E-8 (25 C)

Density

1.344 g/cm3

pKa/pKb

8.83 (pKa)

Partition Coefficient

0

Heat Of Vaporization

70.7 kJ/mol

Usage

Potent cardiotonic, positive inotropic vasodilator.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store at 2-8 C

Hazards Identification

Inhalation

Toxic if inhaled. Material may be irritating to

Skin

May cause skin irritation. Toxic if absorbed through skin.

Eyes

May cause eye irritation.

Ingestion

Toxic if swallowed.

Hazards

Emits toxic fumes under fire conditions.

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Toxic by inhalation, in contact with skin and if swallowed. Possible sensitizer. Target organ(s): Heart. Smooth muscle.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

III