Product Identification

Product Name

Domperidone

Synonyms

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
KW-5338
Motilium
Peridon

CAS

57808-66-9

Formula

C22H24ClN5O2

Molecular Weight

425.92

EINECS

260-968-7

RTECS

DE2275900

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,3476

Beilstein/Gmelin

903774

Beilstein Reference

5-24-02-00402

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

236 - 239

pKa/pKb

4.80 (pKb)

Usage

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves.

Respirators

Government approved respirator.

Exposure Effects

Harmful. Possible risk of harm to the unborn child. Possible risk of impaired fertility. Target organ(s): G.I. System.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.