Product Identification

Product Name

Methyl p-tosylate

Synonyms

Methyl 4-methylbenzenesulfonate
Methyl p-toluenesulfonate
Methyl tosylate

CAS

80-48-8

Formula

C8H10O3S

Molecular Weight

186.23

EINECS

201-283-5

RTECS

XT7000000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Primary Irritant

Beilstein/Gmelin

609209

Beilstein Reference

4-11-00-00247

EC Class

harmful, irritant, sensitizing

Physical and Chemical Properties

Appearance

White or light brown crystals, liquid above 28 deg c.

Solubility in water

Slightly soluble

Melting Point

28 - 30

Boiling Point

292

Vapor Pressure

0.0033 (25 C)

Density

1.2087 g/cm3 (40 C)

Partition Coefficient

1.3

Heat Of Vaporization

51.0 kJ/mol

Usage

Methylating agent in organic synthesis.

Vapor Density

6.45

Refractive Index

1.5184 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

Harmful if swallowed. Causes digestive tract irritation.

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

EC Risk Phrase

R 22 36/37/38 40 43

EC Safety Phrase

S 26 28 36/37/39 45

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Poison Class

3

Fire Fighting Measures

Flash Point

130

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Water or foam may cause frothing.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

1

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents - strong acids - strong bases.

Decomposition

Carbon monoxide, oxides of sulfur, carbon dioxide.

Transport Information

UN Number

2810

HS Code

2905 19 00