Product Identification

Product Name

Actinomycin D

Synonyms

3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
Actinomycin C1
Actinomycin D
Actinomycin I
Actinomycin I1
Actinomycin X 1

CAS

50-76-0

Formula

C62H86N12O16

Molecular Weight

1255.44

EINECS

200-063-6

RTECS

AU1575000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant

Merck

12,2867

Beilstein/Gmelin

605235

Physical and Chemical Properties

Appearance

Bright red crystalline powder.

Solubility in water

1 g in 25 ml of @ 10 C

Melting Point

246 - 247

pKa/pKb

11.90 (pKa)

Partition Coefficient

3.21 @ pH of 7.4

Usage

Medication (vet).

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water. Destroy contaminated shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause loss of hearing. May cause neuromuscular paralysis.

Inhalation

May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation may produce coughing, nausea, and pulmonary edema.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

May cause severe eye irritation. May cause eye injury.

Hazards

Contact with metals may evolve flammable hydrogen gas.

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

241

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Wash area with soap and water. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong bases, strong acids

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III