Product Identification

Product Name

(11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione

Synonyms

Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy, cyclic-16,17-acetal with acetone
Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-

CAS

3093-35-4

Formula

C24H32ClFO5

Molecular Weight

454.97

EINECS

221-439-6

RTECS

TU5010200

RTECS Class

Drug; Mutagen

Merck

12,4621

Beilstein/Gmelin

1358242

Beilstein Reference

5-19-06-00301

Physical and Chemical Properties

Solubility in water

4E-15 (25 C)

pKa/pKb

13.25 (pKa)

Heat Of Vaporization

97.4 kJ/mol

Usage

A topical steroid. Used to treat inflammation caused by a number of conditions such as allergic reactions, eczema, and psoriasis.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

63

EC Safety Phrase

36

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Exposure Effects

Harmful. Possible risk of harm to the unborn child.

Fire Fighting Measures

Flash Point

295

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide.