Product Identification

Product Name

2-Amino-5-fluorotoluene

Synonyms

2-Amino-5-fluorotoluene
2-Fluoro-o-toluidine
2-Methyl-4-fluoroaniline
6-Amino-3-fluorotoluene
Benzenamine, 4-fluoro-2-methyl-

CAS

452-71-1

Formula

C7H8FN

Molecular Weight

125.14

EINECS

207-208-2

RTECS

CY0500000

RTECS Class

Mutagen

Beilstein/Gmelin

1931798

Beilstein Reference

4-12-00-01786

Physical and Chemical Properties

Appearance

Clear pink - red liquid.

Solubility in water

Slightly soluble

Melting Point

14

Boiling Point

207

Vapor Pressure

0.23 (25 C)

Density

1.1263 g/cm3 (18 C)

pKa/pKb

4.51 (pKa)

Partition Coefficient

1.61

Heat Of Vaporization

44.3 kJ/mol

Vapor Density

4.32

Refractive Index

1.5308 (18 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Inhalation

Aspiration may lead to pulmonary edema. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia. Inhalation at high concentrations may cause CNS depression and asphixiation.

Skin

Absorption into the body may cause cyanosis. May cause irritation and dermatitis. May cause cyanosis of the extremities.

Eyes

May cause chemical conjunctivitis and corneal damage.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Overexposure may cause methemoglobinemia.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 20/21/22 33 36/38

EC Safety Phrase

S 26 36/37/39

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Effects may be delayed.

Fire Fighting Measures

Flash Point

87

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2810

Hazard Class

6.1

Packing Group

I; II; III