Product Identification

Product Name

4-Nitrosophenol

Synonyms

1,4-Benzoquinone monoxime
Nitrosophenol
para-Nitrosophenol
Quinone monoxime
Quinone oxime

CAS

104-91-6

Formula

C6H5NO2

Molecular Weight

123.11

EINECS

203-251-6

RTECS

SM4725000

RTECS Class

Mutagen

Merck

12,6740

Beilstein/Gmelin

1856695

Beilstein Reference

4-07-00-02073

EC Index Number

604-042-00-6

EC Class

Mutagenic Category 3; Harmful; Irritant; Dangerous for the Environment

Physical and Chemical Properties

Appearance

Yellow to brown powder.

Solubility in water

8 g/L

Melting Point

130

Boiling Point

266

Vapor Pressure

0.005 (25 C)

pKa/pKb

6.48 (pKa)

Partition Coefficient

1.43

Heat Of Vaporization

52.4 kJ/mol

Heat Of Combustion

-3005 kJ/mol

Usage

Manufacture of dyes.

First Aid Measures

Ingestion

Dilution - may enhance absorption of phenol, and should be avoided. Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Activated charcoal - may limit systemic toxicity if administered soon after ingestion, but may interfere with endoscopic evaluation of gastrointestinal burns.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Flammables-area.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Tachypnea is commonly reported; pulmonary edema and bronchospasm may also occur. Stridor has been reported from exposure to high concentrations of phenol. Respiratory arrest occurred 30 minutes post ingestion of 26.7 Grams of phenol in one case.

Skin

Phenol is corrosive to the skin, but because of anesthetic qualities, it will numb rather than causing a burning pain on contact. Skin becomes red and swollen, then white and opaque. Deep burns result that may become gangrenous.

Eyes

May cause eye irritation and possible damage.

Ingestion

Phenol is extremely corrosive and may cause oral and esophageal burns and abdominal pain following ingestion.

Exposure Controls/Personal Protection

Personal Protection

Wear protective safety goggles or face shield as described in 29 CRF 1910.133 or European Standard EN166. Skin contact should be eliminated by wearing the appropriate chemical protective gloves annd clothing.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.

Poison Class

1

Fire Fighting Measures

Flash Point

115

Autoignition

390

Fire Fighting

Wear a self-contained breathing apparatus inpressure-demand, MSHA/NIOSH (approved or equivalent), and fullprotective gear. This material poses an explosion hazard when dry.Flammable solid. In case of fire use water spray, dry chemical, carbon dioxide, orchemical foam.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong acids, bases.

Decomposition

Carbon monoxide, oxides of nitrogen, carbon dioxide.