Product Identification

Product Name

L-5-Pyrrolidone-2-carboxylic acid

Synonyms

2-L-Pyrrolidone-5-carboxylic acid
5-Oxo-L-proline
5-Oxoproline
Glutimic acid
Pidolic acid
Pyrrolidonecarboxylic acid

CAS

98-79-3

Formula

C5H7NO3

Molecular Weight

129.12

EINECS

202-700-3

RTECS

TW3710000

RTECS Class

Drug

Merck

12,8185

Beilstein/Gmelin

82132

Beilstein Reference

5-22-06-00007

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Very soluble

Melting Point

154 - 162

Boiling Point

309

Density

1.455 g/cm3

pKa/pKb

3.47 (pKa)

Usage

Substance is used in the resolution of racemic amines.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation. The toxicological properties of this material have not been fully investigated.

Eyes

Dust may cause mechanical irritation. Causes eye irritation.

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 26 36

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate clothing to prevent skin exposure.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Acids, bases.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Transport Information

HS Code

2933 79 00