Product Identification

Product Name

6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol

Synonyms

(8R,9S)-Quinidine
6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
a-(6-Methoxy-4-quinolyl)-5-Vinyl-2-quinuclidinemethanol
Cinchonan-9-ol, 6'-methoxy-(95)
Conchinin
Pitayine

CAS

56-54-2

Formula

C20H24N2O2

Molecular Weight

324.42

EINECS

200-279-0

RTECS

VA4725000

RTECS Class

Drug; Primary Irritant

Merck

12,8244

Beilstein/Gmelin

91866

Beilstein Reference

5-23-13-00395

Physical and Chemical Properties

Appearance

Crystals or white powder.

Solubility in water

Insoluble

Melting Point

174-175

pKa/pKb

4.87 (pKb)

Partition Coefficient

2.88

Usage

Medication.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting only when instructed to do so by a physician.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Do not ingest or inhale. Use only in a chemical fume hood. Do not breathe dust.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

Causes mild skin irritation.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause cardiac effects such as heart blocks, arrhythmias, shock and possible death due to cardiovascular collapse. May result in severe disturbances of cardiac conduction and hypotension accompanied by central nervous system toxicity. May cause decreased kidney function resulting in severe intoxication. In patients with preexisting cardiovascular disease, pulmonary edema may occur.

EC Risk Phrase

R 22

EC Safety Phrase

S 22 36/37

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Chronic exposure may cause blood effects. Repeated exposure may cause stomach pains, vomiting, and diarrhea. Pe ople with preexisting heart conditions, asthma, muscle weakness, kidne y or liver insufficiencies, infection or fever should avoid quinidine.

Poison Class

3

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or water spray.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures. Darkens on exposure to light.

Incompatibilities

Strong oxidizing agents, direct light.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.