Product Identification

Product Name

Flumazenil

Synonyms

4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl ester
Anexate
Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate
Flumazepil
Lanexat

CAS

78755-81-4

Formula

C15H14FN3O3

Molecular Weight

303.29000000000002

RTECS

NI2922170

Merck

12,4169

Beilstein/Gmelin

4763661

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

201 - 203

Boiling Point

528

Vapor Pressure

3.1E-11 (25 C)

Density

1.39 g/cm3 (20 C)

pKa/pKb

12.86 (pKb)

Partition Coefficient

.87

Heat Of Vaporization

80.3 kJ/mol

Usage

Used as an antidote in the treatment of benzodiazepine overdose. .

Handling and Storage

Storage

Store in original container in a cool dark place.

Hazards Identification

Inhalation

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

Skin

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

Eyes

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Ingestion

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products

Emits toxic fumes under fire conditions.